NORI has developed a method to support cancer treatment through implementing a methionine restricted diet. Foods lowest in methionine while providing calories, vitamins and minerals are fruits and select vegetables. There is nothing inherently dangerous or nutritionally deficient in a diet consisting of only fruits and vegetables. In fact, a diet of only fruits and vegetables will provide every nutritional requirement without the need to consume grains, nuts, seeds and legumes. Fruits and vegetables are the foods most compatible with human physiology and our evolutionary path. Dark green leafy vegetables provide more than adequate protein, calcium, iron and magnesium. B12 is the only limiting nutritional factor in a 100% plant-based diet and should be provided by supplementation. Cancer patients are advised to discontinue B12 supplementation during treatment because B12 is a tumor growth promoter.

Among a growing number of nutrition experts, it is well accepted that optimal health is gained by the elimination of meats, dairy, eggs and seafood. Protein needs are highly exaggerated and anti-aging studies point directly at excess protein as the primary factor in limiting lifespan. High animal protein diets are associated with every degenerative disease including most forms of cancer. Animal protein causes a massive imbalance in the gut microbiome which leads to autointoxication, inflammation and colorectal cancer. Animal protein consumption creates acidity in the body, taxes the liver and kidneys, increases plasma ammonia and uric acid. Real protein requirements may be in the range of only 10-20 grams per day for an average adult. Protein is not utilized for energy production. The body can not directly utilize protein as it must be digested and broken down into individual amino acids. Amino acids are building blocks for protein synthesis.

The amino acid, leucine is a branched chain amino acid that cancer cells require for growth and proliferation. A recent study[1] demonstrates that estrogen sensitive (MCF-7) and triple negative (MDA-MB-231) breast cancer cells die when deprived of leucine. This study utilized both in vitro and in vivo experimental models which support clinical application. Dietary leucine drives cancer cell proliferation by stimulating the mTOR signaling pathway. Other studies suggest that leucine is critical for prostate, pancreatic and melanoma tumor growth.

Leucine is found primarily in animal foods but is also abundant in soy, nuts, seeds and beans. The NORI methionine restricted diet highly limits leucine intake in addition to other amino acids that are potentially critical for cancer cell growth. The NORI dietary approach is like fasting but better because there is intake of calories, fiber, vitamins and minerals. One feels better, has an abundance of energy and will not suffer from muscle wasting provided that there is sufficient caloric intake.

The NORI methionine restricted diet is cycled for various reasons but it may be possible that a continuous long-term methionine restricted diet may be more beneficial than a short term cycled diet. Keep in mind that NORI utilizes a methionine restricted diet as a foundation only, not an actual treatment. This is because there are many tumor growth factors that can overcome the tumor growth limiting effects of the diet. The purpose of implementing a methionine restricted diet is to slow tumor growth and increase susceptibility of cancer cells to various treatment modalities. The NORI approach is not to dump nutrients into the system in an attempt to build or boost the immune system or activate any internal cancer healing mechanisms. The human body does not possess any inherent mechanisms for fighting cancer. Cancer will proliferate in all of us regardless of our health or immune system status. Cancer is not a disease or failure of any internal system or a nutritional deficiency. Cancer is an environmental injury and specifically damage to the mitochondrial DNA of stem cells. The solution to cancer is to take advantage of metabolic targets and lowering of all tumor growth stimulating factors win a natural and nontoxic manner. Drugs will never be the complete answer to developing a cure.

In conclusion, a high-fruit or all-fruit diet may be the best approach to target metabolic vulnerabilities within cancer cells to slow tumor growth and sensitize cancer cells to various treatment options.

References

[1] Xiao, F., Wang, C., Yin, H., Yu, J., Chen, S., Fang, J., & Guo, F. (2016). Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase. Oncotarget, 7(39), 63679–63689. http://doi.org/10.18632/oncotarget.11626

See Dr. Michael Greger’s articles and videos on cancer, animal protein and diabetes at www.nutritionfacts.org

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