The NORI Protocol
There are two major goals of the NORI protocol. The first is to slow down tumor growth. The main component for slowing tumor growth is a methionine restricted diet. There are other factors that provide additional tumor growth inhibitory effects that are associated with the NORI dietary approach.
The second goal is to trigger apoptosis in cancer cells using commonly available natural and nontoxic compounds. There are numerous choices avaialble. NORI has selected among thousands of options and narrowed the selection to just a few that have very strong scientific support and fit within the overall approach. The NORI protocol exploits the primary vulnerability of cancer cells which is the regulation of oxidative stress. Cancer cells are barely surviving under a very high level of oxidative stress while normal cells are at a very low level. By depleting antioxidant capacity of cancer cells and elevating ROS (reactive oxygen species) within cancer cells, a critical condition is created that triggers the natural process of apoptosis. Normal cells easily survive the elevation of oxidative stress while cancer cells succumb.
An important feature of the NORI protocol is the synergy created between the methionine restricted diet and high dose selenium. Methionine restriction sensitizes cancer cells to sodium selenite by lowering glutathione which increases oxidative stress.
The NORI protocol is intended to complement conventional cancer therapy and is not intended as a standalone therapy. NORI recommends that all cancer patients seek appropriate medical care and make informed choices based on science-based evidence.
Cancer is best treated through an integrative approach that incorporates many elements including targeted nutrition, stress reduction, lifestyle modifications and weighing the risks and benefits of all treatment options. Information overload is probably the biggest challenge for the cancer patient, especially when researching all of the alternative treatment options. NORI offers consultations to help one sort through the enormous maze and find the most effective path towards long term management.
Methionine Restricted Diet
Nutrition is a powerful tool in controlling tumor growth as well as making cancer cells much more susceptible to treatment. The trick is in supporting normal healthy cells while depriving cancer cells of essential nutrients. Cancer cells are highly dependent on several different amino acids for growth and cell division. Cancer cells are universally dependent on methionine. It is both practical and effective to limit the dietary intake of methionine as a means to starve cancer cells of this essential nutrient. Normal cells are unharmed by short term limitation of methionine. Methionine restriction is very powerful and may be sufficient as a standalone therapy for many early stage cancers. Click here to read an article on dietary methionine restriction published in 2001 by Dr Epner.
NORI does not encourage or support the use of certain nutritional supplements, herbs and juicing during cancer treatment. It is believed that these elements only help cancer cells grow and survive. NORI believes that certain B vitamins such as B12, B1 and B9 can encourage tumor growth. NORI also believes that antioxidants support cancer cell survival. Prime examples are NAC and glutathione.
The idea of building and boosting the immune system is not a central core of the NORI approach. Cancer cells very effectively evade the immune system so immune enhancement is not emphasized within the NORI protocol.
It is strongly recommended that one seeks professional assistance in implementing a methionine restricted diet. NORI offers such guidance through our home-based nutritional support program. Contact NORI for details.
Methionine restriction is individualized for each patient according to weight, nutritional status, disease progression and past dietary preferences. A methionine restricted diet may be continuous or cycled on and off depending on individual circumstances. Methionine restriction involves the elimination of many foods and a focus on mostly fruits. The natural sugars in fruits will not feed cancer cells or cause tumors to grow. It is a common misconception that fruit equals sugar and that fruits raise blood sugar. Fruit can be a problem if there is a high fat intake (greater than 10% of total caloric intake) which will cause insulin resistance.
High Dose Selenium
Selenium is an essential trace element found in foods and nutritional supplements. Studies have shown that selenium not only can prevent cancer but can also treat it. Click here to read one of the best papers on treating cancer with selenium by Eric Olm, PhD.
Sodium selenite is the most effective form of selenium for therapeutic use. Cancer cells are triggered to self destruct (apoptosis) when exposed to sodium selenite at low concentrations. Normal healthy cells are unharmed unlike treatment with conventional chemotherapy. Sodium selenite can be administered intravenously or by the use of a specially formulated sublingual tablet.
Sodium selenite is combined with two other natural compounds to boost the effect so that very safe and low doses can be used very effectively. The mechanism of action is pro-oxidative through a simple chemical reaction that generates excess reactive oxygen species within the mitochondria which releases a cascade of signals triggering apoptosis.
NORI does not sell therapeutic level sodium selenite supplements and IV solutions to individuals. Sodium selenite is available to patients who are receiving care from an affiliated physician or who are participating in the NORI nutritional support program. The types and dosages of selenium available in health food stores and online will not have therapeutic value. Selenized yeast at 200 mcg per day is the best form for cancer prevention.
Genipin is a compound present in gardenia fruit extract (Zhi Zi) that has been found to inhibit a mitochondrial protein called UCP2. Genipin has been shown to trigger apoptosis through the generation of excess reactive oxygen species (ROS) by increasing the level of ATP generated by mitochondria. UCP2 maintains the cancer cell at a low level of oxidative stress by keeping the level of mitochondrial oxidative phosphorylation minimized. Gardenia fruit extract (Zhi Zi) has been used in traditional Chinese medicine for thousands of years. Current scientific studies are demonstrating potent and selective anti-tumor activity.
Vitamin E Succinate
The semi-synthetic form of vitamin E, vitamin E succinate (VES) has been extensively studied as a cancer preventative and chemotherapeutic agent. NORI incorporates VES within a powerful cocktail designed to induce apoptosis through the generation of excess oxidative stress. VES has no antioxidant activity and is synergistic with the pro-oxidant effects of sodium selenite. VES reacts directly with mitochondrial complex II generating ROS and has been shown to trigger apoptosis in over 90% of cancer cell types. VES is completely nontoxic to normal cells. NORI uses a transdermal VES formulation. Oral adminstration of VES is ineffective because the succinate portion of the molecule is hydrolyzed in the gut.
A Simple but Powerful Approach
The NORI protocol provides cancer patients with a set of tools to enhance their treatment plan and post treatment recovery. Successful cancer treatment and long term management requires many elements beyond the standard of care. NORI offers cancer patients an opportunity to enhance their care to a level well beyond the standard options of chemotherapy, radiation and surgery. Every treatment option has its risks, benefits, costs and quality of life issues. Choosing treatment options is very challenging and requires careful research and decision making. Always seek multiple opinions.
Scientific References Supporting the NORI Protocol
This is only a partial sampling of the scientific studies that form the foundation of the NORI Protocol. The links below will take you to the original published articles.
Vitamin K3 (Menadione)
Menadione (Vitamin K3) Induces Apoptosis of Human Oral Cancer Cells and Reduces their Metastatic Potential by Modulating the Expression of Epithelial to Mesenchymal Transition Markers and Inhibiting Migration
Vitamin E Succinate
Pine Bark (Pycnogenol) and Grape Seed Extract
Green Tea Extract
NORI believes that cannabis derivatives may offer enormous therapeutic benefits to those suffering from cancer. We have incorporated the use of CBD into our program.